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. 2021 Aug 10;22(4):721. doi: 10.3892/ol.2021.12982

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — HDAC1 induces aerobic glycolysis in endometrial cancer cells. (A) Glucose consumption, (B) lactate secretion and (C) ATP levels were assessed in HEC-1-A cells infected with OE-NC, OE-HDAC1, sh-NC or sh-HDAC1-1/-2. (D) Expression levels of HIF-1α, PKM2 and LDHA were measured by western blotting. N=3, ANOVA followed by Tukey test; *P<0.05, sh-HDAC1 group vs. sh-NC group; ^#P<0.05, OE-HDAC1 group vs. OE-NC group). HDAC1, histone deacetylase 1; sh, short hairpin; OE, overexpression; HIF-1α, hypoxia-inducible factor 1; PKM2, pyruvate kinase PKM; LDHA, L-lactate dehydrogenase A chain.