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. 2021 Aug 10;22(4):725. doi: 10.3892/ol.2021.12986

Table III.

Receiver operating characteristic analysis of circulating biomarkers individually and combined for gastric cancer detection.

Models AUC (95% CI) Cut-off Sensitivity, % Specificity, % Youden index J P-value
One-dimensional model
  miR-130b 0.887 (0.821–0.935) 0.18 91.11 71.11 0.6222
  PDW,% 0.840 (0.766–0.898) 15.31 70.45 97.78 0.6823
  MLR 0.814 (0.738–0.876) 0.15 80.90 75.56 0.5645
  Hb, g/l 0.828 (0.753–0.888) 127.00 68.54 84.44 0.5298
Dual-model
  miR-130b-PDW 0.922 (0.863–0.961) 0.74 82.02 88.89 0.7091 <0.0001a, 0.0005b
  miR-130b-MLR 0.892 (0.827–0.939) 0.76 75.28 86.67 0.6195 <0.0001a, 0.1541c
  miR-130b-Hb 0.937 (0.882–0.972) 0.56 89.89 86.67 0.7655 <0.0001a, 0.0014d
  PDW-MLR 0.843 (0.769–0.900) 0.53 71.26 97.78 0.6904 0.5030b, 0.5662c
  PDW-Hb 0.945 (0.891–0.977) 0.50 89.66 88.89 0.7854 0.0003b, 0.0001d
  MLR-Hb 0.835 (0.761–0.893) 0.64 73.03 84.44 0.5748 0.6893c, 0.0940d
Tri-model
  miR-130b-PDW-MLR 0.955 (0.905–0.984) 0.61 94.25 91.11 0.8536 0.0921e, 0.0091f, 0.0005g
  miR-130b-PDW-Hb 0.976 (0.933–0.995) 0.77 90.80 97.78 0.8858 0.0602e, 0.0218h, 0.0341i
  miR-130b-MLR-Hb 0.942 (0.888–0.975) 0.52 91.01 86.67 0.7768 0.0095f, 0.0697h, 0.0012j
  PDW-MLR-Hb 0.947 (0.894–0.978) 0.55 89.66 91.11 0.8077 0.0004g, 0.2198i, 0.0002j
Tetrad-model
  miR-130b-PDW-MLR-Hb 0.978 (0.936–0.996) 0.76 91.95 97.78 0.8973 0.0651k, 0.1465l, 0.0277m, 0.0316n
a

Compared with the AUC of miR-130b.

b

Compared with the AUC of PDW.

c

Compared with the AUC of MLR.

d

Compared with the AUC of Hb.

e

Compared with the AUC of miR-130b-PDW.

f

Compared with the AUC of miR-130b-MLR.

g

Compared with the AUC of PDW-MLR.

h

Compared with AUC of miR-130b-Hb.

i

Compared with the AUC of PDW-Hb.

j

Compared with the AUC of MLR-Hb.

k

Compared with the AUC of miR-130b-RDW-MLR.

l

Compared with the AUC of miR-130b-PDW-Hb.

m

Compared with the AUC of miR-130b-MLR-Hb.

n

Compared with the AUC of PDW-MLR-Hb. AUC, area under the curve; 95% CI, 95% confidence interval; miR-130b, microRNA-130b; PDW, platelet distribution width; MLR, monocyte to lymphocyte count ratio; Hb, hemoglobin.