Table IX.

Accuracy of circulating biomarkers individually and combined for Pre detection.

Pre vs. NC	AUC (95% CI)	Cut-off	Youden index J	Sensitivity, %	Specificity, %	Accuracy, %	LR+	LR−	DOR
RDW-CV	0.649 (0.557–0.733)	12.40	0.2808	63.64	64.44	63.94	1.79	0.56	3.17
MPV/PC ratio	0.687 (0.597–0.768)	0.04	0.2973	51.95	77.78	61.48	2.34	0.62	3.78
MLR	0.713 (0.624–0.791)	0.12	0.3792	77.92	60.00	71.31	1.95	0.37	5.29
NLR	0.616 (0.524–0.702)	3.12	0.3506	35.06	100.00	59.01	–	0.65	–
PDW	0.811 (0.730–0.877)	15.31	0.7015	72.37	97.78	81.74	32.60	0.28	115.37
L%	0.638 (0.546–0.723)	21.71	0.3377	33.77	100.00	58.20	–	0.66	–
M%	0.649 (0.558–0.733)	4.50	0.2547	57.14	68.89	61.47	1.84	0.62	2.95
M#	0.657 (0.565–0.741)	0.25	0.2974	69.74	60.00	66.15	1.74	0.50	3.46
Hb	0.679 (0.588–0.761)	127.00	0.3250	48.05	84.44	61.47	3.09	0.62	5.02
miR-130b-MLR	0.687 (0.597–0.768)	0.68	0.4343	54.55	88.89	67.22	4.91	0.51	9.60
miR-130b-PDW	0.896 (0.827–0.944)	0.51	0.7623	82.89	93.33	86.77	12.43	0.18	67.79
MLR-PDW	0.816 (0.736–0.881)	0.51	0.7146	73.68	97.78	82.64	33.19	0.27	123.30
miR-130b-MLR-PDW	0.896 (0.827–0.944)	0.51	0.7623	82.89	93.33	86.77	12.43	0.18	67.79

Pre, precancerous lesions; NC, healthy control; AUC, area under the curve; 95% CI, 95% confidence interval; LR⁺, positive likelihood ratio; LR⁻, negative likelihood ratio; DOR, diagnostic odds ratio; miR-130b, microRNA-130b; RDW-CV, red blood cell distribution width-coefficient of variation; MPV/PC, mean platelet volume to platelet count ratio; MLR, monocyte to lymphocyte count ratio; NLR, neutrophil to lymphocyte ratio; PDW, platelet distribution width; L%, lymphocyte percentage; M%, monocyte percentage; M#, monocyte count; Hb, hemoglobin.