Table VI.
Receiver operating characteristic analysis of circulating biomarkers individually and combined for early stage gastric cancer detection.
| Models | AUC (95% CI) | P-value |
|---|---|---|
| One-dimensional model | ||
| miR-130b | 0.9110 (0.8417–0.9805) | |
| RDW-CV,% | 0.7130 (0.5770–0.8490) | |
| NLR | 0.6491 (0.5082–0.7900) | |
| PDW,% | 0.8037 (0.6616–0.9458) | |
| M% | 0.7367 (0.6196–0.8539) | |
| R#,1012/l | 0.7019 (0.5715–0.8322) | |
| Hb, g/l | 0.7745 (0.6563–0.8928) | |
| Hct,% | 0.6935 (0.5601–0.8269) | |
| MLR | 0.7610 (0.6430–0.8560) | |
| Dual-model | ||
| miR-130b-PDW | 0.9560 (0.877–0.991) | 0.3775a; 0.0576b |
| miR-130b-Hb | 0.9230 (0.833–0.974) | 0.7412a; 0.0181c |
| PDW-Hb | 0.9060 (0.812–0.963) | 0.1731b; 0.0464c |
| Tri-model | ||
| miR-130b-PDW-Hb | 0.960 (0.883–0.993) | 0.2250d; 0.4331e; 0.0940f |
a
Compared with the AUC of miR-130b.
b
Compared with the AUC of PDW.
c
Compared with the AUC of Hb.
d
Compared with the AUC of miR-130b-PDW.
e
Compared with the AUC of miR-130b-Hb.
f
Compared with the AUC of PDW-Hb. AUC, area under the curve; 95% CI, 95% confidence interval; miR-130b, microRNA-130b; RDW-CV, red blood cell distribution width-coefficient of variation; NLR, neutrophil to lymphocyte ratio; PDW, platelet distribution width; M%, monocyte percentage; R#, red blood cell count; Hb, hemoglobin; Hct, hematocrit; MLR, monocyte to lymphocyte ratio.