Table VII.
Accuracy of miR-130b, PDW and Hb individually and combined for early stage gastric cancer detection.
| Variable | Cut-off | Youden index J | Sensitivity, % | Specificity, % | Accuracy, % | LR+ | LR− | DOR |
|---|---|---|---|---|---|---|---|---|
| miR-130b | −2.15 | 0.71 | 95.56 | 75.00 | 82.15 | 3.82 | 0.06 | 64.57 |
| RDW-CV,% | 12.80 | 0.38 | 58.33 | 80.00 | 72.46 | 2.92 | 0.52 | 5.60 |
| NLR | 2.04 | 0.27 | 62.50 | 64.44 | 63.77 | 1.76 | 0.58 | 3.02 |
| PDW,% | 15.31 | 0.77 | 79.17 | 97.78 | 91.31 | 35.66 | 0.21 | 167.41 |
| M% | 4.20 | 0.38 | 73.91 | 64.44 | 67.64 | 2.08 | 0.40 | 5.13 |
| R#,1012/l | 4.61 | 0.31 | 70.45 | 97.78 | 88.27 | 31.73 | 0.30 | 105.01 |
| Hb, g/l | 134 | 0.46 | 83.33 | 62.22 | 69.56 | 2.21 | 0.27 | 8.23 |
| Hct,% | 36.10 | 0.35 | 41.67 | 93.33 | 75.36 | 6.25 | 0.62 | 10.00 |
| MLR | 0.10 | 0.49 | 100.00 | 48.89 | 66.67 | 1.95 | – | – |
| miR-130b-PDW | 0.26 | 0.94 | 95.83 | 97.78 | 97.10 | 43.17 | 0.04 | 1,012.19 |
| miR-130b-Hb | 0.40 | 0.74 | 83.33 | 91.11 | 88.40 | 9.37 | 0.18 | 51.23 |
| PDW-Hb | 0.31 | 0.79 | 83.33 | 95.56 | 91.31 | 18.77 | 0.17 | 107.59 |
| miR-130b-PDW-Hb | 0.29 | 0.94 | 95.83 | 97.78 | 97.10 | 43.17 | 0.04 | 1,012.19 |
LR+, positive likelihood ratio; LR−, negative likelihood ratio; DOR, diagnostic odds ratio; miR-130b, microRNA-130b; RDW-CV, red blood cell distribution width-coefficient of variation; NLR, neutrophil to lymphocyte ratio; PDW, platelet distribution width; M%, monocyte percentage; R#, red blood cell count; Hb, hemoglobin; Hct, hematocrit; MLR, monocyte to lymphocyte ratio.