Table VIII.
Receiver operating characteristic analysis of circulating biomarkers individually and combined for precancerous lesion detection.
| Models | AUC (95% CI) | P-value |
|---|---|---|
| One-dimensional model | ||
| miR-130b | 0.700 (0.613–0.788) | |
| RDW-CV, % | 0.649 (0.557–0.733) | |
| MPV/PC ratio | 0.687 (0.597–0.768) | |
| MLR | 0.713 (0.624–0.791) | |
| NLR | 0.616 (0.524–0.702) | |
| PDW, % | 0.811 (0.730–0.877) | |
| L% | 0.638 (0.546–0.723) | |
| M% | 0.649 (0.558–0.733) | |
| M# 109/l | 0.657 (0.565–0.741) | |
| Hb, g/l | 0.679 (0.588–0.761) | |
| Dual-model | ||
| miR-130b-MLR | 0.687 (0.597–0.768) | 0.8154a; 0.7273b |
| miR-130b-PDW | 0.896 (0.827–0.944) | <0.0001a; 0.0028c |
| MLR-PDW | 0.816 (0.736–0.881) | 0.1069b; 0.0832c |
| Tri-model | ||
| miR-130b-MLR-PDW | 0.896 (0.827–0.944) | 0.0001d; 0.6849e; 0.0049f |
a
Compared with the AUC of miR-130b.
b
Compared with the AUC of MLR.
c
Compared with the AUC of PDW.
d
Compared with the AUC of miR-130b-MLR.
e
Compared with the AUC of miR-130b-PDW.
f
Compared with the AUC of MLR-PDW. AUC, area under the curve; 95% CI, 95% confidence interval; miR-130b, microRNA-130b; RDW-CV, red blood cell distribution width-coefficient of variation; MPV/PC, mean platelet volume to platelet count ratio; MLR, monocyte to lymphocyte count ratio; NLR, neutrophil to lymphocyte ratio; PDW, platelet distribution width; L%, lymphocyte percentage; M%, monocyte percentage; M#, monocyte count; Hb, hemoglobin.