Table 9.
Biomarker results among men in intervention and nonintervention groups at baseline, 1 week before and 12 weeks after prostatectomy.a
| Intervention | Nonintervention | Between arm changes | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Biomarker/component | Baseline | Pre-surgery | Post-surgery | Pwithinb | Baseline | Pre-surgery | Post-surgery | Pwithinb | Pbetweenc |
| Hs-CRP (mg/L) | 1.5 ± 1.1 (15) | 1.7 ± 1.5 (14) | 2.6 ± 4.8 (13) | 0.97 | 4.3 ± 5.1 (5) | 1.7 ± 0.6 (3) | 2.6 ± 1.9 (4) | 0.75 | 0.43 |
| Total cholesterol (mg/dL) | 185.6 ± 37.7 (15) | 177.6 ± 47.8 (14) | 181.2 ± 36.1 (13) | 0.54 | 201.6 ± 32.4 (5) | 215.7 ± 46.1 (3) | 185.3 ± 31.9 (4) | 0.25 | 0.21 |
| HDL cholesterol (mg/dL) | 53.2 ± 14.2 (15) | 54.7 ± 14.0 (14) | 52.9 ± 11.6 (13) | 0.43 | 54.2 ± 13.5 (5) | 46.3 ± 8.5 (3) | 54.8 ± 14.7 (4) | 1.00 | 0.28 |
| LDL cholesterol (mg/dL) | 107.6 ± 28.8 (14) | 104.2 ± 38.6 (14) | 106.9 ± 26.4 (13) | 0.53 | 120.0 ± 29.1 (5) | 130.5 ± 57.3 (2) | 100.3 ± 27.4 (4) | 0.50 | 0.17 |
| Triglycerides (mg/dL) | 132.3 ± 154.6 (15) | 92.8 ± 35.7 (14) | 106.9 ± 52.1 (13) | 0.94 | 137.4 ± 73.6 (5) | 220.7 ± 165.0 (3) | 151.8 ± 135.8 (4) | 0.59 | 0.57 |
| C-peptide (ng/mL) | 2.3 ± 1.4 (15) | 1.5 ± 0.6 (14) | 1.8 ± 1.0 (13) | 0.01 | 2.4 ± 1.4 (5) | 2.4 ± 2.0 (3) | 2.1 ± 1.2 (4) | 0.75 | 0.30 |
| FBG (mg/dL) | 108.8 ± 26.9 (15) | 98.6 ± 15.9 (14) | 104.7 ± 28.7 (13) | 0.06 | 103.4 ± 14.3 (5) | 102.0 ± 8.9 (3) | 104.3 ± 11.0 (4) | 1.00 | 0.49 |
| Fasting insulin (μIU/mL) | 8.8 ± 7.0 (15) | 5.5 ± 2.7 (14) | 8.3 ± 8.1 (13) | 0.03 | 10.1 ± 6.3 (5) | 8.4 ± 5.5 (3) | 7.7 ± 3.4 (4) | 0.75 | 0.71 |
| Leptin:adiponectin ratio | 1.325 ± 1.424 (15) | 0.794 ± 0.981 (13) | 1.339 ± 2.191 (13) | 0.008 | 0.914 ± 0.606 (5) | 0.799 ± 0.629 (3) | 0.834 ± 0.841 (4) | 0.75 | 0.30 |
| Resistin (ng/mL) | 24.7 ± 9.9 (15) | 24.7 ± 10.9 (13) | 28.3 ± 8.0 (13)d | 0.50 | 25.9 ± 7.1 (5) | 28.8 ± 3.4 (3) | 35.0 ± 1.5 (4) | 1.00 | 0.80 |
| Metabolic syndrome | 33.0% (5/15) | 14.3% (2/14) | 30.1% (4/13) | N/A | 40% (2/5) | 66.7% (2/3) | 25% (1/4) | N/A | N/A |
a
Values represent mean ± SD (n) or % (participants affected/total participants). hs-CRP, high sensitivity C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FBG, fasting blood glucose.
b
P value within arms; from baseline to pre-surgery.
c
P value between arms; change from baseline to pre-surgery.
d
P value < 0.05 from baseline value; all other net changes were not significant.