eTable. Weight-adjusted dosage recommendations on medications for malaria prophlaxis*1 modified from (23).
Body weight (kg) | Age | Tablets/day Atovaquone/proguanil 62.5/25 mg (junior)*2 | Tablets/dayDoxycycline 100 mg*2 | Tablets/week Mefloquine 250 mg*2 |
5–9 | < 4 months | ½ (up to 8 kg BW, off-label use) | – | ⅛ tablet |
9–11 | 4–11 months | ¾ (from 8 kg BW, off-label use) | – | ¼ tablet |
11–15 | 1–2 years | 1 | – | ¼ tablet |
15–19 | 3–4 years | 1 | – | ¼ + ⅛ tablet |
19–25 | 5–7 years | 1; or 2 from 21 kg BW | – | ½ tablet |
25–36 | 8–10 years | 2; or 3 from 31 kg BW | ½ | ½–¾ tablet |
36–50 | 11–13 years | 3 ‘junior’ tablets; or 1 tablet for adults (250/100 mg) from 40 kg BW | ¾ | ¾–1 tablet |
> 50 | > 13 years | 1 tablet for adults (250/100 mg) | 1 | 1 tablet |
*1 Atovaquone/proguanil (‚junior‘ formulation), doxycycline and mefloquine.
*2 A commercially available pill splitter is recommended for pill splitting. Attention should always be paid to the respective valid product information.