Figure 6.

M1 inactivation effects modulated by the consistency of learned movements. A, The effect of M1 inactivation on the fraction of incorrect target entry as a function of the movement consistency (i.e., the trial-to-trial trajectory correlation) of each animal that was computed from their last 11 training sessions for each direction separately. Different colors for different mice. For illustration purposes, inactivation effects for each animal were shown as mean ± SE across their inactivation sessions. Solid circles represent PV-Cre mice with virally expressed ChR2. Empty circles represent PV-Cre::Ai32 mice. The dependence of inactivation effect on the movement consistency was estimated using a linear mixed-effect model, similar to Figure 4B, but movement consistency that continuously varied across animals was used as the independent variable. B, The effect of M1 inactivation on the mean target acquisition time as a function of movement consistency. The same format and statistical test as in A. C, The effect of M1 inactivation on the variability of target acquisition time as a function of movement consistency. The same format and statistical test as in A. Inactivation effects on the fraction of incorrect target entry, mean target acquisition time, and variability of target acquisition time showed significantly negative slopes (Table 1), indicating that effects decrease proportionally with movement consistency.