TABLE 2.
Predicted effect of missense SNPs on TEX19 protein structure and function
| SNP ID | AA | PolyPhen−2 (score) | PhD | SNPs and GO | SIFT |
|---|---|---|---|---|---|
| rs377629628 | M1T | Probably damaging (0.998) | Neutral | Neutral | Deleterious |
| rs371327683 | P4L | Probably damaging (1.000) | Neutral | Neutral | Deleterious |
| rs761018318 | P4A | Probably damaging (1.000) | Neutral | Neutral | Deleterious |
| rs900962762 | S6G | Probably damaging (0.969) | Neutral | Neutral | Deleterious |
| rs1245990387 | S6R | Probably damaging (0.997) | Neutral | Neutral | Deleterious |
| rs868177850 | R8W | Probably damaging (0.999) | Disease | Neutral | Deleterious |
| rs1318138374 | H27Q | Probably damaging (0.998) | Neutral | Neutral | Deleterious |
| rs150740969 | C34Y | Probably damaging (0.993) | Disease | Disease | Deleterious |
| rs367711836 | F35S | Probably damaging (0.999) | Neutral | Neutral | Deleterious |
| rs1257967420 | C37S | Probably damaging (0.999) | Disease | Disease | Deleterious |
| rs1185108733 | A41V | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs1259349893 | A41S | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs116114329 | E50A | Probably damaging (1.000) | Neutral | Neutral | Deleterious |
| rs1156477833 | E50D | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs1599669625 | E55L | Probably damaging (0.997) | Neutral | Neutral | Deleterious |
| rs1385130699 | D60N | Probably damaging (0.998) | Neutral | Neutral | Deleterious |
| rs1331784175 | P61R | Probably damaging (0.962) | Neutral | Neutral | Tolerated |
| rs1266481991 | L63M | Probably damaging (0.987) | Neutral | Neutral | Tolerated |
| rs761225499 | W83R | Probably damaging (0.991) | Neutral | Neutral | Tolerated |
| rs1390892071 | W83C | Probably damaging (0.998) | Neutral | Neutral | Tolerated |
| rs1319739886 | P90H | Probably damaging (0.99) | Neutral | Neutral | Tolerated |
| rs777468964 | Q92H | Probably damaging (0.965) | Neutral | Neutral | Tolerated |
| rs147220016 | G93W | Probably damaging (0.997) | Neutral | Neutral | Deleterious |
| rs140570015 | G99R | Probably damaging (0.979) | Neutral | Neutral | Deleterious |
| rs1372613314 | A104E | Probably damaging (0.997) | Neutral | Neutral | Tolerated |
| rs1184019063 | P121S | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs1403014449 | P126S | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs1599669625 | Q127L | Probably damaging (0.979) | Neutral | Neutral | Deleterious |
| rs1479032497 | P131L | Probably damaging (0.99) | Neutral | Neutral | Deleterious |
| rs200970555 | G135S | Probably damaging (0.998) | Neutral | Neutral | Deleterious |
| rs1439503805 | W141R | Probably damaging (1) | Disease | Neutral | Deleterious |
| rs1276048234 | Q143H | Probably damaging (1) | Neutral | Neutral | Deleterious |
| rs771614199 | G144C | Probably damaging (0.997) | Neutral | Neutral | Deleterious |
| rs759919288 | W147R | Probably damaging (1) | Disease | Neutral | Deleterious |
| rs933781675 | W158C | Probably damaging (1) | Disease | Neutral | Deleterious |
| rs767149161 | P159S | Probably damaging (0.979) | Neutral | Neutral | Tolerated |