Table 3.
Proteins associated with cognitive stimulation in 2261 participants with plasma proteins available in Whitehall subcohort after controlling for multiple testing (analysis 2)
| Protein | High v low cognitive stimulation | Medium v low cognitive stimulation | |||
|---|---|---|---|---|---|
| β (SE)* | P value | β (SE)* | P value | ||
| Pulmonary surfactant associated protein D (SP-D) | −0.32 (0.06) | <0.001 | -0.17 (0.06) | 0.002 | |
| Slit homologue 2 protein (SLIT2) | −0.30 (0.06) | <0.001 | −0.17 (0.06) | 0.002 | |
| Hexokinase 2 (HXK2) | −0.28 (0.06) | <0.001 | −0.13 (0.06) | 0.019 | |
| Carbohydrate sulfotransferase 12 (CHSTC) | −0.28 (0.06) | <0.001 | −0.08 (0.06) | 0.18 | |
| Peptidyl-glycine α-amidating monooxygenase (AMD) | −0.28 (0.06) | <0.001 | −0.12 (0.06) | 0.03 | |
| Neutrophil cytosol factor 1 (NCF-1) | −0.27 (0.06) | <0.001 | −0.06 (0.06) | 0.28 | |
*
Per 1 standard deviation higher protein level. Only statistically significant associations after adjustment for age, sex, ethnicity, and Bonferroni correction for multiple testing (P<1.0×10−5) are shown for high versus low cognitive stimulation.