In vitro activity of S-MGBs and reference compounds against MRSA and T. b. brucei.
Compound | S. aureus MIC (μM) | E. faecalis MIC (μM) | T. b. brucei EC50 (μM) |
---|---|---|---|
2 | 6.25 | 25 | 0.78 |
3 | 1.56 | 3.12 | 1.56 |
4 | 0.2 | 0.78 | <0.19 |
5 | >50 | >50 | >50 |
6 | >50 | >50 | >50 |
7 | >50 | >50 | >50 |
8 | >50 | >50 | >50 |
9 | >50 | >50 | >50 |
10 | >50 | >50 | 3.12 |
11 | >50 | >50 | 6.25 |
Vancomycin | 0.39 | 6.25 | — |
Diminazene | — | — | 0.5 |