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. 2021 Jul 6;12(8):1391–1401. doi: 10.1039/d1md00110h

In vitro activity of selected S-MGBs and reference compounds against L. donovani, T. congolense, T. vivax and L6 rat myoblast cell line (mean ± SEM, n ≥ 3). The EC50 value was calculated from 3 separate experiments.

Compound EC50 (μM)
L. donovani T. congolense T. vivax L6
10 1.6 ± 0.90 0.87 ± 0.21 0.76 ± 0.13 6.7 ± 1.1
11 NA 6.6 ± 0.8 6.9 ± 1.2 41 ± 3.1
Amphotericin B 0.10 ± 0.00
Diminazene 0.13 ± 0.02 0.17 ± 0.03