In vitro activity of selected S-MGBs and reference compounds against L. donovani, T. congolense, T. vivax and L6 rat myoblast cell line (mean ± SEM, n ≥ 3). The EC50 value was calculated from 3 separate experiments.
| Compound | EC50 (μM) | |||
|---|---|---|---|---|
| L. donovani | T. congolense | T. vivax | L6 | |
| 10 | 1.6 ± 0.90 | 0.87 ± 0.21 | 0.76 ± 0.13 | 6.7 ± 1.1 |
| 11 | NA | 6.6 ± 0.8 | 6.9 ± 1.2 | 41 ± 3.1 |
| Amphotericin B | 0.10 ± 0.00 | — | — | — |
| Diminazene | — | 0.13 ± 0.02 | 0.17 ± 0.03 | — |