Table 2.

A list of initial values.

Parameter	Description	Value	Source
nG(0)	*Initial density of tumor cell (2×104 cell·mm−3)	1	Set as normalization unit
nm1(0)+nm2(0)	*Initial density of TAM	2	Experimental
n T,total	*Amount of T cell added to blood vessel converted to density in TME	30	Experimental
n T	*Estimated density of extravasated CD8+ T cell into TME by integral of Eq. (6) (clinically, the density of CTLs in TME)	Dual/CSF-1R inhibition for all patients: 8 PD-1 inhibition/Control: Patient 1: 5.101 Patient 2: 5.646 Patient 3: 5.723 Patient 4: 3.718 Patient 5: 4.213 Patient 6: 5.864 Patient 7: 6.054 Patient 8: 2.507 Patient 9: 5.486	Fitted with experimental data
$c_{\text{CSF}1}\frac{n_{\text{G}}\left(0\right)}{K_{\text{CSF}1\left(\text{R}\right)}}$	*The concentration of CSF-1 secreted by tumor, normalized with cell density and the CSF-1 concentration for half-maximal activation of CSF-1(R) pathway. Deduced from the patient-various M2 TAM	Patient 1: 7.375 Patient 2: 5.453 Patient 3: 5.210 Patient 4: 16.746 Patient 5: 13.069 Patient 6: 5.359 Patient 7: 4.736 Patient 8: 32.717 Patient 9: 6.716	Experimental