Table 3. Characteristics of the randomized cohort.
| Intervention | ID | Age | Sex | Neglect severity | Days from stroke to T1 | Days to complete interventions (T2-T1) | Days to follow-up (T3-T2) | Aetiology | Lesion location | Visual field deficit | Inpatient/Outpatient at time of intervention | SAEs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| tDCS | 1 | 78 | M | High | 34 | 23 | Died | I | Right temporo-occipital + thalamus | Y | IP | Unrelated: DVT + PTE, died |
| 2 | 56 | M | High | 495 | 16 | 264 | I | Right PCA (temporo-occipito-parietal + basal ganglia) | Y | IP | – | |
| 3 | 61 | F | Low | 39 | 15 | 179 | I | Right MCA | N | OP | – | |
| 4 | 67 | F | Low | 1394 | 34 | 192 | H | Right fronto-parietal | N | OP | – | |
| 5 | 64 | M | Low | 786 | 66 | 181 | H | Right parietal | N | OP | – | |
| 6 | 70 | F | Low | 68 | 47 | 178 | I | Right MCA | N | OP | – | |
| Median | 66 | 282 | 28.5 | 181 | ||||||||
| Behavioural training | 7 | 54 | M | High | 38 | 19 | Lost Contact | I | Right MCA | Not testable | IP | – |
| 8 | 79 | M | High | 74 | 46 | 193 | I | Right PCA | Y | OP | – | |
| 9 | 75 | M | Low | 32 | 42 | 217 | I | Right MCA + temporal | N | OP | – | |
| 10 | 72 | F | Low | 37 | 15 | Died | I | Right fronto-parietal | Y | IP | Unrelated: died | |
| 11 | 59 | F | Low | 2020 | 43 | Lost Contact | H | Right fronto-parietal | N | OP | – | |
| 12 | 62 | M | Low | 55 | Withdrew | Withdrew | H | Right basal ganglia | N/A tested | OP | – | |
| Median | 67 | 47 | 42 | 205 | ||||||||
| Combined intervention | 13 | 84 | F | High | 36 | Unable | Withdrew | I | Right uncus, hippocampus, internal capsule, pons and cerebellum | Y | IP | – |
| 14 | 73 | F | High | 34 | 60 (6/10 sessions) | Lost Contact | I | Right MCA | Not testable | IP | – | |
| 15 | 65 | M | Low | 45 | 21 | 193 | I | Right fronto-parietal + temporo-occipital + thalamus | Y | OP | Unrelated: new onset seizures | |
| 16 | 62 | M | Low | 1727 | 28 | 192 | I | Right MCA | N | OP | – | |
| 17 | 73 | F | Low | 75 | 51 | 189 | I | Nil new, old right frontal | N | OP | – | |
| 18 | 66 | F | Low | 426 | 44 | Lost Contact | I | Right MCA | N | OP | – | |
| Median | 70 | 60 | 44 | 192 | ||||||||
| Control training | 19 | 45 | F | High | 38 | 36 | Lost Contact | I | Right MCA | N | IP | – |
| 20 | 60 | M | High | 78 | 11 | 229 | I | Right MCA + internal capsule | Y | IP | Unrelated: PTE | |
| 21 | 76 | M | Low | 39 | 25 | 199 | I | Right MCA | Y | OP | – | |
| 22 | 67 | F | Low | 1859 | Withdrew | Withdrew | I | Right MCA | N/A | OP | – | |
| 23 | 63 | M | Low | 1028 | 29 | 210 | I | Right parietal | N | OP | – | |
| 24 | 52 | M | Low | 458 | 38 | 227 | H | Right fronto-parietal | Y | OP | – | |
| Median | 62 | 268 | 29 | 218.5 |
Note: Neglect Severity: high = BIT score of <115. Visual Field Deficit: not testable: 2 patients could not be assessed due to their inability to sustain attention sufficiently to complete the test, N/A: 2 patients withdrew before the in-house testing could be performed. Unable: the patient could not tolerate the tDCS montage as experienced severe itching and was unable to carry out behavioural training. T1: time of baseline secondary outcome measure testing, T2: time of post-intervention testing, T3: time of follow-up testing. SAE: Serious Adverse Event. DVT: Deep Vein Thrombosis. PTE: Pulmonary Thromboembolism. IP: inpatient. OP: outpatient.