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. 2021 Aug 4;11:705627. doi: 10.3389/fonc.2021.705627

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Copyright © 2021 Abbas, Mohanty, Wang, Huang, Liang, Wang, Zhang, Qiu, Hu, Qutub, Dail, Bolen, Daver, Konopleva, Futreal, Chen, Wang and Kornblau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic analysis: (A) Differential protein expression analysis comparing group 3 with group 1. Upregulated proteins (q < 0.1 and difference in mean > 0.32) are shown in red and downregulated proteins (q < 0.1 and difference in mean > -0.188) in blue. (B) Scatterplot illustrating the correlation between expression of mTOR.pS2448 (activating phosphorylation) and MCL1 (spearman correlation = 0.322, p = 0.003). (C, D) Scatterplot illustrating the expression of phosphorylated S6 (marker of mTOR activation) with venetoclax (higher area under the curve [AUC] indicates more resistance to treatment). Statistics computed using Spearman correlation.