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. 2021 Apr 29;80(9):1227–1235. doi: 10.1136/annrheumdis-2020-219624

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Manhattan plot of a genome-wide association analysis of chronic widespread musculoskeletal pain (CWP). Each circle in the plot represents a single nucleotide polymorphism (SNP), which was positioned following genomic build GRCh37. The y-axis shows the corresponding –log10 p values and the x-axis shows chromosome position along with SNPs. The horizontal red dotted line indicates genome-wide significance threshold at p=5.0×10^–8. The horizontal blue dotted line indicates suggestive genome-wide significance threshold at p=5.0×10^–7. Gene labels represent nearest genes to independent SNPs located at loci associated with p<5.0×10^–7.