Table 1.
Sample characteristics stratified by case/control status for discovery and replication cohorts
| Cases | Controls | P value | |
| Discovery cohort (UK Biobank) | |||
| Female | 4470 (64.7%) | 128 599 (47.1%) | <0.0001 |
| Male | 2444 (35.3%) | 114 330 (52.9%) | |
| Age (mean±SD) | 57.8±7.45 | 57.0±8.09 | <0.0001 |
| BMI (mean±SD) | 30.02±5.97 | 26.83±4.40 | <0.0001 |
| Replication cohorts | |||
| TwinsUK | |||
| Female | 1041 (93.7%) | 3116 (87.6%) | <0.0001 |
| Male | 70 (6.3%) | 440 (12.4%) | |
| Age (mean±SD) | 54.78±10.48 | 50.12±13.21 | <0.0001 |
| BMI (mean±SD) | 27.39±5.11 | 25.74±4.57 | <0.0001 |
| HUNT | |||
| Female | 6315 | 5836 | <0.0001 |
| Male | 4241 | 7403 | |
| Age (mean±SD) | 55.95±9.48 | 54.82±10.31 | <0.0001 |
| BMI (mean±SD) | 27.37±4.33 | 26.52±3.88 | <0.0001 |
| ELSA | |||
| Female | 1090 (64.9%) | 2660 (50.2%) | <0.001 |
| Male | 589 (35.1%) | 2644 (49.8%) | |
| Age (mean±SD) | 68.10±9.49 | 66.55±9.98 | <0.0001 |
| BMI (mean±SD) | 28.60±4.98 | 27.08±4.22 | <0.0001 |
| RS-1 | |||
| Female | 422 | 1323 | <0.0001 |
| Male | 110 | 1281 | |
| Age (mean±SD) | 64.49±5.30 | 64.60±5.24 | 0.6660 |
| BMI (mean±SD) | 26.98±3.91 | 26.14±3.54 | <0.0001 |
| RS-2 | |||
| Female | 106 | 745 | <0.0001 |
| Male | 38 | 676 | |
| Age (mean±SD) | 61.59±4.59 | 61.93±4.72 | 0.2651 |
| BMI (mean±SD) | 28.54±4.73 | 27.77±3.91 | 0.0363 |
| RS-3 | |||
| Female | 128 | 1516 | <0.0001 |
| Male | 27 | 1263 | |
| Age (mean±SD) | 56.28±5.77 | 56.32±5.46 | 0.0348 |
| BMI (mean±SD) | 28.54±4.86) | 27.71±4.62 | 0.0827 |
BMI, body mass index; ELSA, The English Longitudinal Study of Ageing; HUNT, The Nord-Trøndelag Health Survey; RS-1, RS-2 and RS-3, The Rotterdam Study 1, 2 and 3; SD, Standard deviation.