Table 2.

Regression model for analysing time to first clinical relapse

Time to first relapse	HR	95% CI	P value
Sex (male (57) vs female (113; ref.))	0.707	0.415 to 1.206	0.203
Age (<34 years (84; ref.) vs ≥34 years (86))	1.201	0.729 to 1.981	0.472
Annualised relapse rate at baseline	1.460	1.098 to 1.940	0.009
Baseline-EDSS	1.004	0.805 to 1.252	0.973
Disease duration since onset (yrs)	0.945	0.891 to 1.003	0.062
Last previous DMT (naïve=ref. (35)) basic (52)	0.930	0.410 to 2.110	0.983
NTZs (21)	2.732	1.138 to 6.560	0.025
NTZa (29)	3.888	1.375 to 10.990	0.010
FTY (33)	5.420	2.520 to 11.660	<0.001

Results from our Cox proportional hazard model using an enter method to integrate all the covariates in the final analysis. For analysis of age as a covariate, we split our group according to the median. Reference categories are indicated for categorical covariates. Numbers in brackets in the first column indicate sample numbers for the respective covariate.

Bold values indicate p-values below 0.05

DMT, disease-modifying treatment; EDSS, Expanded Disability Status Scale; FTY, fingolimod; NTZa, natalizumab (previously active); NTZs, natalizumab (active subgroup).