Table 3.

Regression model for analysing time to confirmed worsening of disability

Time to first confirmed worsening of disability	HR	95% CI	P value
Sex (male (57) vs female (113; ref.))	0.768	0.400 to 1.473	0.427
Age (<34 years (84; ref.) vs ≥34 years (86))	1.312	0.703 to 2.447	0.394
Annualised relapse rate at baseline	1.239	0.879 to 1.748	0.221
Baseline-EDSS	0.972	0.750 to 0.1260	0.829
Disease duration since onset (yrs)	0.964	0.905 to 1.027	0.258
Last previous DMT (naïve=ref. (35)) basic (52)	0.855	0.279 to 2.615	0.783
NTZs (21)	1.533	0.349 to 6.723	0.571
NTZa (29)	2.92	0.868 to 8.349	0.086
FTY (33)	7.676	2.870 to 20.534	<0.001

Results from our Cox proportional hazard model using an enter method to integrate all covariates in the final analysis. For analysis of age as a covariate, we split our group according to the median. Reference categories are indicated for categorical covariates. Numbers in brackets in the first column indicate sample numbers for the respective covariate.

DMT, disease-modifying treatment; EDSS, Expanded Disability Status Scale; FTY, fingolimod; NTZa, natalizumab (previously active); NTZs, natalizumab (stable subgroup).