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. 2021 May 13;80(9):1147–1157. doi: 10.1136/annrheumdis-2020-219014

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Response rates for (A) ACR20, (B) ACR50 and (C) ACR70 through week 52. Supporting values shown in online supplemental table S3. Missing responses were imputed as non-responses. Shown for randomised patients who received ≥1 dose of study drug. TIL 200 mg Q4W, n=78; TIL 200 mg Q12W, n=79; TIL 100 mg Q12W, n=77; TIL 20 mg Q12W→200 mg Q12W, n=78; PBO Q4W→TIL 200 mg Q12W, n=79. ^*p<0.05; ^†p<0.001; ^‡p<0.0001 versus PBO; not adjusted for multiplicity, except ACR20 at week 24. P values were not analysed beyond week 24. ACR, American College of Rheumatology; PBO, placebo; Q4W, every 4 weeks; Q12W, every 12 weeks; TIL, tildrakizumab.