Table 1.
Levels of critical process parameters, critical quality attributes, and quality target product profile for the preparation of drug-LPH using the Box-Behnken design.
| Critical process parameters (CPPs) (Coded independent variables) |
Levels |
||
|---|---|---|---|
| Low (-1) |
Medium (0) |
High (1) |
|
| A: PLGA (mg) B: Drug (mg) C: Stirring speed (rpm) |
5 10 500 |
10 15 750 |
15 20 1000 |
| Critical quality attributes (CQAs) Quality target product profile (QTPP) (Responses) (Constraints) | |||
| Y1: Particle size (nm) Y2: Zeta potentiel (mV) Y3: EE(%)a |
Minimize Maximize Maximize |
||
a EE% = Encapsulation efficiency parentage.