Table 1.
Gene Ontology (GO) enrichment analysis using 1341 overlapping DEGs between male and female dataset.
| GO of Biological Process (BP) | No. of Gene | Adjust.p-value |
|---|---|---|
| nucleosome assembly | 35 | 2.49E-13 |
| DNA conformation change | 50 | 4.58E-13 |
| DNA packaging | 41 | 4.58E-13 |
| mitotic nuclear division | 45 | 8.59E-13 |
| chromatin assembly | 35 | 3.30E-12 |
| protein-DNA complex assembly | 40 | 2.14E-11 |
| nucleosome organization | 35 | 2.70E-11 |
| chromosome segregation | 46 | 2.84E-11 |
| chromatin assembly or disassembly | 36 | 4.23E-11 |
| sister chromatid segregation |
33 |
1.34E-10 |
|
GO of Cellular Component (CC) |
No. of Gene |
Adjust.p-value |
| DNA packaging complex | 37 | 2.95E-19 |
| nucleosome | 35 | 1.41E-18 |
| chromosomal region | 59 | 1.02E-16 |
| condensed chromosome | 1.39E-15 | |
| kinetochore | 32 | 4.28E-13 |
| condensed chromosome kinetochore | 28 | 4.28E-13 |
| chromosome | 6.14E-15 | |
| protein-DNA complex | 38 | 5.41E-13 |
| condensed chromosome | 38 | 3.90E-12 |
| collagen-containing extracellular matrix |
52 |
7.17E-10 |
|
GO of Molecular Function (MF) |
No. of Gene |
Adjust.p-value |
| protein heterodimerization activity | 56 | 3.07E-06 |
| heparin binding | 21 | 0.002536 |
| sulfur compound binding | 27 | 0.002536 |
| extracellular matrix structural constituent | 21 | 0.005097 |
| glycosaminoglycan binding | 24 | 0.005741 |
| icosanoid receptor activity | 5 | 0.015201 |
| cGMP binding | 5 | 0.015201 |
| peptidase regulator activity | 22 | 0.015201 |
| extracellular matrix binding | 9 | 0.015201 |
| amyloid-beta binding | 11 | 0.043064 |