Table 1.

Characteristics of the included studies.

Study ID	Region, country	Study design	No. of COVID-19a	Diagnosis of COVID-19	Reasons for PE screening	Ratiob	No. of CTPAc	No.of PEd	Qualitye
Fauvel C (Bompard et al., 2020)	France	retrospective, multi-center, multi-hospital	2878	RT-PCR+, clinical criteria	unexplained respiratory deterioration	67.5%	1240	103	8
Poyiadji N (Fauvel et al., 2020)	Detroit, USA	retrospective, multi-hospital	–	RT-PCR+	–	–	328	72	8
Mestre-Gómez B (Flumignan et al., 2020)	Madrid, Italy	retrospective, single non-critical ward	452	RT-PCR +, clinical criteria	unexplained respiratory deterioration, elevation of D-dimer	–	91	29	9
Alonso-Fernánde A (Fox et al., 2020)	Palma de Mallorca, Spain	prospective, single hospital	127	RT-PCR +, clinical criteria	D-dimer > 1 mg/L	96.7%	30	15	8
Fang C (Grillet et al., 2020)	London, UK	retrospective, single hospital	1200	RT-PCR+	–	–	93	41	8
Chen JP (Jalaber et al., 2020)	Wuhan, China	retrospective, single hospital	1008	15 RT-PCR+, 10 clinical criteria	elevated D-dimer, PE symptom(s)	–	25	10	9
Leonard-Lorant I (Huisman et al., 2018)	Strasbourg, France	Retr ospective, 2 hospitals	–	97 RT-PCR+, 9 clinical criteria	–	46.2%	106	32	8
Bompard F (Kim et al., 2007)	Paris, France	retrospective, 2 hospitals	–	–	respiratory deterioration	100%	135	32	8
Ooi MWX (Kirsch et al., 2020)	GreaterManchester, UK	retrospective, 5 hospitals	974	RT-PCR+, clinical criteria	respiratory deterioration, elevation of D-dimer	–	84	32	9
Ventura-Diaz S (Konstantinides et al., 2019)	Madrid, Spain	retrospective, single hospital	–	RT-PCR+, clinical criteria	–	–	242	73	8
Kirsch B (Kosior et al., 2020)	Houston, USA	retrospective, single hospital	459	–	–	–	64	12	7
Planquette B (Kunutsor and Laukkanen, 2020)	Paris, France	retrospective, 2 hospitals	–	RT-PCR +, clinical criteria	–	34.6%	269	59	8
Mouhat B (Lax et al., 2020)	Besançon, France	retrospective, single hospital	349	RT-PCR+	unexplained respiratory deterioration	87%	162	44	9
Whyte MB (Léonard-Lorant and Delabranche, 2020)	London, UK	retrospective, single hospital	–	145 RT-PCR, 69 Clinical criteria	unexplained clinical deterioration	100%	214	80	9
Grillet F (Liao et al., 2020)	Besancon Cedex, France	retrospective, single hospital	280	RT-PCR+, clinical criteria	–	–	100	23	8
Bavaro DF (Llitjos et al., 2020)	Bari, Italy	retrospective, single hospital	–	–	D-dimer > 1 mg/L and clinically suspected PE	85%	20	8	8
Benito N (Mestre-Gómez et al., 2020)	Barcelona, Spain	prospective, single hospital	1275	RT-PCR+	unexplained circulatory/ respiratory deterioration, elevation of D-dimer	88.2%	76	32	9
Gervaise A (Mouhat et al., 2020)	Saint Mandé, France	retrospective, single ED	–	58 RT-PCR +, 14 clinical criteria	respiratory deterioration, elevation of D-dimer	–	72	13	9
Contou D (Mueller-Peltzer et al., 2020)	Argenteuil, France	retrospective, single ICU	92	RT-PCR +	unexplained circulatory/ respiratory deterioration	100%	26	16	9
Zotzmann V (Nopp et al., 2020)	Freiburg, Germany	retrospective, single ICU	113	RT-PCR +	severe ARDS	–	20	12	9
Soumagne T (Ooi et al., 2020)	Besancon, France	retrospective, single ICU	–	RT-PCR +	respiratory deterioration	81.8%	44	17	9
Taccone FS (Pandey and Agarwal, 2020)	Brussels, Belgium	retrospective, single ICU	82	RT-PCR +	mechanical ventilation	100%	40	13	9
Jevnikar M (Planquette et al., 2021)	Le Kremlin-Bicêtre, France	prospective, multi-center, multi-hospital	135	RT-PCR +	systematic screening	–	107	16	9
Jalaber C (Rodriguez-Sevilla et al., 2020)	Saint Priest en Jarez, France	prospective, single ED	70	65 RT-PCR+, 5 clinical criteria	systematic screening	–	70	4	9
Ameri P (Poyiadji et al., 2020)	Italy	retrospective, multi-center, 13 cardiology units	689	RT-PCR +, clinical criteria	–	–	–	52	8
Lascarrou JB (Salje et al., 2020)	France and Belgium	retrospective, multi-center, 21 ICU	375	RT-PCR +	–	100%	–	55	8
Scudiero F (Scudiero et al., 2021)	Seriate, Italy	retrospective, multi-center, 7 hospitals	224	RT-PCR +	–	18.8%	–	32	8

Abbreviations: COVID-19, coronavirus disease 2019; PE, pulmonary embolism; CTPA, computed tomography pulmonary angiography; RT-PCR+, positive reverse transcription-polymerase chain reaction; ICU, intensive care unit; ED, emergency department

^aNo. of COVID-19, number of patients with COVID-19

^bRatio, ratio of prophylactic anticoagulation

^cNo. of CTPA, number of patients with CTPA examination or suspicion of PE

^dNo. of PE, number of patients with confirmed PE

^eQuality, all studies were assessed by the Newcastle Ottawa Score (NOS); –, not available