Figure 1.

Study profile, stratified by SARS-CoV-2 serostatus

27 participants (21 HIV-negative people and six people with HIV) were excluded from this interim analysis because of a positive SARS-CoV-2 PCR test within the trial period. Three participants were excluded from the immunogenicity analysis owing to an absence of baseline serology. 12 participants (one withdrawn and 11 positive SARS-CoV-2 PCR tests) did not receive a booster dose. Three participants were excluded from analysis at day 42 as they were lost to follow-up. FLS=full length spike. RBD=receptor-binding domain. *One or more samples were not determined due to insufficient sample volume, haemolysis, or sample not collected.