Table 2.
Association AMH with difference in menstrual cycle lengtha, long menstrual cycles, and short menstrual cycles
| AMH (ng/mL) | No. of cycles | Adjustedb Δ in cycle length (days) (95% CI)e | Adjustedc Δ in cycle length (days) (95% CI)e | |
|---|---|---|---|---|
| Linear AMH, per 1 ng/mL increase | 1880 | 0.30 (0.24, 0.36) | 0.30 (0.24, 0.36) | |
| <1.6 | 568 | –1.00 (–1.48, –0.53) | –0.98 (–1.46, –0.50) | |
| 1.6-3.4 | 606 | Reference | ||
| >3.4-8 | 558 | 1.32 (0.86, 1.78) | 1.35 (0.88, 1.82) | |
| >8 | 148 | 2.08 (1.40, 2.77) | 2.15 (1.46, 2.83) | |
| Long cycles (>35 days) | aOR (95% CI) b | aOR (95% CI) c | aOR (95% CI) d | |
| <1.6 | 430 | 0.67 (0.39, 1.16) | 0.64 (0.36, 1.14) | 0.93 (0.46, 1.86) |
| 1.6-3.4 | 534 | Reference | ||
| >3.4-8 | 566 | 1.68 (1.10, 2.59) | 1.69 (1.08, 2.65) | 1.79 (1.06, 2.99) |
| >8 | 191 | 4.73 (2.86, 7.84) | 4.92 (2.89, 8.36) | 4.41 (2.41, 8.06) |
| Short cycles (<25 days) | aOR (95% CI) b | aOR (95% CI) c | aOR (95% CI) d | |
| <1.6 | 567 | 1.65 (1.19, 2.28) | 1.61 (1.14, 2.26) | 1.96 (1.32, 2.89) |
| 1.6-3.4 | 596 | Reference | ||
| >3.4-8 | 521 | 0.46 (0.30, 0.70) | 0.44 (0.28, 0.68) | 0.59 (0.36, 0.96) |
| >8 | 135 | 0.46 (0.23, 0.90) | 0.42 (0.21, 0.85) | 0.24 (0.11, 0.53) |
a To achieve normality of the model residuals, the continuous analysis was limited to cycles between 22 and 36 days long.
b Adjusted for age.
c Adjusted for age, race, education, BMI, time since oral contraceptive use, alcohol, smoking, and caffeine consumption.
d Sensitivity analysis of the association of categorical AMH with long and short cycles weighted by the inverse of cycles contributed by each woman (fully adjusted).
e All comparison P values were <.001.