Table 1.
Baseline characteristics of the general analytic sample by pro-neurotensin/neuromedin N quartilea
| Characteristic (mean [95% CI] or %) | |||||
|---|---|---|---|---|---|
| Pro-NT/NMN quartiles | No. missing | Q1 (9-118 pmol/L) | Q2 (119-164 pmol/L) | Q3 (165-226 pmol/L) | Q4 (227-1430 pmol/L) |
| No. | 943 | 943 | 943 | 943 | |
| Age, y | 0 | 62.7 (62.1 to 63.3) | 63.4 (62.9 to 64.0) | 62.6 (62.1 to 63.1) | 63.3 (62.8 to 63.9) |
| Black race | 0 | 23.5 | 30.1 | 39.5 | 53.6 |
| Male sex | 0 | 48.5 | 45.2 | 44.1 | 39.9 |
| Tobacco use, pack-years | 83 | 10.6 (9.3 to 11.9) | 10.3 (9.0 to 11.5) | 9.5 (8.3 to 10.7) | 11.2 (9.7 to 12.6) |
| Current alcohol use | 58 | ||||
| None | 51.2 | 54.3 | 59.5 | 66.0 | |
| Moderate | 42.3 | 39.0 | 36.8 | 31.4 | |
| Heavy | 6.5 | 6.7 | 3.7 | 2.6 | |
| Weekly exercise frequency | 53 | ||||
| None | 26.5 | 25.8 | 30.9 | 32.3 | |
| 1-3 times | 38.0 | 40.4 | 39.0 | 38.9 | |
| ≥ 4 times | 35.6 | 33.8 | 30.1 | 28.9 | |
| Body mass index | 16 | 28.4 (28.0 to 28.7) | 28.8 (28.4 to 29.1) | 29.7 (29.3 to 30.1) | 30.5 (20.1 to 30.9) |
| Waist circumference, cm | 12 | 94 (92 to 95) | 94 (94 to 95) | 96 (95 to 97) | 98 (97 to 99) |
| Systolic blood pressure, mm Hg | 4 | 124 (123 to 125) | 125 (124 to 126) | 125 (124 to 126) | 127 (126 to 128) |
| Glucose, mg/dL | 0 | 167 (162 to 173) | 160 (154 to 166) | 152 (146 to 158) | 138 (132 to 145) |
| Insulin, mIU/L | 640b | 10.4 (9.8 to 10.9) | 11.3 (10.8 to 11.9) | 12.6 (11.7 to 13.6) | 15.8 (14.6 to 17.1) |
| HOMA-IR | 640b | 4.0 (3.7 to 4.2) | 4.1 (3.9 to 4.4) | 4.5 (4.1 to 4.8) | 5.0 (4.6 to 5.4) |
| Diabetes mellitus | 0 | 8.8 | 11.5 | 19.2 | 31.9 |
| Metabolic syndrome | 0 | 25.2 | 22.6 | 25.6 | 35.0 |
| Southern diet score | 886 | –0.24 (–0.30 to –0.18) | –0.15 (–0.22 to –0.08) | –0.07 (–0.14 to 0.01) | 0.08 (0.003 to 0.16) |
| Sweets/Fats diet score | 886 | 0.06 (–0.02 to 0.13) | 0.03 (–0.05 to 0.11) | 0.002 (–0.07 to 0.07) | –0.07 (–0.15 to 0.01) |
| Convenience diet score | 886 | 0.09 (0.03 to 0.16) | 0.13 (0.04 to 0.21) | 0.07 (–0.01 to 0.14) | –0.02 (–0.10 to 0.07) |
| Low-density lipoprotein, mg/dL | 59 | 118 (116 to 120) | 117 (115 to 119) | 114 (112 to 116) | 111 (109 to 113) |
| High-density lipoprotein, mg/dL | 17 | 52 (51 to 53) | 52 (51 to 54) | 53 (52 to 55) | 52 (51 to 53) |
| Triglycerides, mg/dL | 3 | 135 (129 to141) | 124 (119 to 129) | 120 (115 to 125) | 127 (122 to 132) |
Abbreviations: HOMA-IR, homeostasis model of insulin resistance; pro-NT/NMN, pro-neurotensin/neuromedin N; Q quartile.
a Weighted to parent cohort and excluding participants not fasting for phlebotomy and missing pro-NT/NMN measurement; n = 3772.
b Insulin was not measured in those with diabetes mellitus at baseline.