Table 2.
Odds ratios (95% CI) for incident metabolic syndrome and diabetes mellitusa
| MetS (564 incident MetS/2770 at risk) | DM (407 incident DM/3030 at risk) | |||
|---|---|---|---|---|
| Per SD log pro-NT/NMN | Above vs below median pro-NT/NMN | Per SD log pro-NT/NMN | Above vs below median pro-NT/NMN | |
| Model 1 | 1.22 (1.11-1.35) | 1.30 (1.07-1.59) | 1.06 (0.94-1.19) | 1.12 (0.90-1.41) |
| Model 2 | 1.20 (1.07-1.34) | 1.25 (1.00-1.57) | 1.10 (0.97-1.24) | 1.15 (0.90-1.47) |
| Model 3 | 1.14 (1.00-1.30) | 1.08 (0.84-1.40) | 1.03 (0.91-1.17) | 1.04 (0.81-1.34) |
| Model 4 | 1.11 (0.96-1.28) | 1.11 (0.96-1.28) | 1.04 (0.90-1.20) | 1.12 (0.84-1.49) |
Median Pro-NT/NMN values: 160 pmol/L (for MetS analyses), 154 pmol/L (for DM analyses).
Covariates in weighted multivariable models: model 1: age, race, sex; model 2: model 1 + waist circumference, smoking (pack-years), weekly exercise frequency, alcohol use, systolic blood pressure, body mass index, low-density lipoprotein, high-density lipoprotein, and triglycerides; model 3: model 2 + HOMA-IR; and model 4: model 3 + Southern, sweets/fats, and convenience diet scores.
Abbreviations: DM, diabetes mellitus; MetS, metabolic syndrome; OR, odds ratio; pro-NT/NMN, pro-neurotensin/neuromedin N.
a Weighted to parent cohort.