Table 4.
Covariate attenuation of association of log pro-neurotensin/neuromedin N with incident metabolic syndromea
| Modelb | OR per SD (95% CI) log pro-NT/NMN | % Attenuation (95% CI)c | |
|---|---|---|---|
| Model 1, with age, race, and sex | 1.22 (1.11 to 1.35) | ||
| Waist circumference | 1.19 (1.08 to 1.32) | 13.3% | (–3.9% to 30.6%) |
| Smoking, pack-years | 1.23 (1.12 to 1.35) | –3.5% | (–14.9% to 7.9%) |
| Weekly exercise frequency | 1.22 (1.11 to 1.35) | -0.8% | (–9.6% to 8.0%) |
| Alcohol use | 1.21 (1.09 to 1.33) | 6.0% | (–3.3% to 15.4%) |
| Systolic blood pressure | 1.22 (1.11 to 1.35) | 0.8% | (–5.9% to 7.5%) |
| Body mass index | 1.17 (1.06 to 1.30) | 21.1% | (–0.4% to 42.6%) |
| Low-density lipoprotein | 1.20 (1.09 to 1.32) | 10.9% | (0.3% to 21.5%) |
| High-density lipoprotein | 1.24 (1.13 to 1.37) | –10.4% | (–27.3% to 6.6%) |
| Triglycerides | 1.24 (1.12 to 1.37) | –7.3% | (–15.9% to 1.3%) |
| HOMA-IR | 1.12 (1.00 to 1.25) | 47.9% | (1.7% to 94.1%) |
| Southern diet score | 1.20 (1.07 to 1.34) | 9.2% | (–23.1% to 41.5%) |
| Sweets/Fats diet score | 1.20 (1.08 to 1.35) | 7.9% | (–24.1% to 39.8%) |
| Convenience diet score | 1.20 (1.07 to 1.34) | 10.1% | (–22.4% to 42.7%) |
n = 2770
Abbreviations: HOMA-IR, homeostatic model assessment of insulin resistance; OR, odds ratio; pro-NT/NMN, pro-neurotensin/neuromedin N.
a Weighted to analytic cohort.
b Each covariate was individually added to model 1.
c Estimates obtained using bootstrapping with 1000 replicate samples.