Table 2.
Upstream regulators identified using ingenuity pathway analysis
| Upstream regulator | Molecule type | Activation Z-score | P of overlap |
|---|---|---|---|
| FOXM1 | Transcription regulator | –2.23 | 1.71 × 10–3 |
| VEGF | Group | –2.87 | 3.46 × 10–5 |
| IL2 | Cytokine | 2.22 | 2.53 × 10–3 |
| ESR1 | Ligand-dependent nuclear receptor | –0.57 | 5.08 × 10–5 |
| ESR2 | Ligand-dependent nuclear receptor | 1.60 | 3.0 × 10–5 |
| Beta-estradiol | Hormone | 0.63 | 3.20 × 10–3 |
| Dexamethasone | Chemical drug | –3.58 | 1.06 × 10–10 |
| SMAD7 | Transcriptional regulator | 3.10 | 9.22 × 10–5 |
| ERBB3 | Kinase | 2.50 | 6.0 × 10–4 |
| ERBB4 | Kinase | 2.06 | 8.87 × 10–5 |
| TGFB1 | Growth Factor | –3.48 | 4.22 × 10–13 |
+Z-score implies activation of downstream molecular pathway in the suboptimal group