Table 3.
Differentially expressed genes (RNA-Seq) that are bound by ERα (ChIP-seq)
| Gene symbol | Fold change** | P | Gene description |
|---|---|---|---|
| ABCA3 | 1.338 | 3.4 × 10–02 | ATP binding cassette subfamily A member 3 |
| *ADAMTS5 | –1.773 | 3.1 × 10–05 | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| ADAMTS8 | –1.361 | 3.6 × 10–02 | ADAM metallopeptidase with thrombospondin type 1 motif 8) |
| ADAMTSL5 | 1.41 | .000117 | ADAMTS-Like Protein 5 |
| AFAP1L2 | –1.522 | .00175 | Actin filament associated protein 1 like 2 |
| AKAP1 | 1.49 | .000435 | A-Kinase Anchoring Protein 1 |
| ALOX5 | –1.3 | .0078 | arachidonate 5-lipoxygenase |
| ANXA5 | –1.351 | .001 | Thromboplastin inhibitor |
| AOC3 | 0.6 | 3.0 × 10–04 | Amine Oxidase Copper Containing 3 |
| ARHGAP26 | 1.567 | .0004 | Rho GTPase activating protein 26 |
| BCL6 | –1.325 | .016 | B cell CLL/lymphoma 6 |
| C1orf198 | –1.381 | .003 | chromosome 1 open reading frame 198 |
| C1QTNF7 | –1.41 | .028 | C1q and TNF related 7 |
| C8orf48 | –1.299 | .0282 | chromosome 8 open reading frame 48 |
| CCBE1 | –1.385 | .0273 | collagen and calcium binding EGF domains 1 |
| CDH2 | –1.302 | .0468 | cadherin 2 |
| CISH | –1.222 | .046 | Cytokine Inducible SH2 Containing Protein |
| COL18A1 | –1.272 | .0396 | collagen type XVIII alpha 1 chain |
| COL21A1 | –1.422 | .0245 | collagen type XXI alpha 1 chain |
| DAB2 | –1.355 | 3.6 × 10–03 | Differentially Expressed Protein 2 |
| EDN2 | –1.511 | .0105 | endothelin 2 |
| FAT4 | –1.451 | .0212 | FAT atypical cadherin 4 |
| FMO1 | –1.488 | .0109 | flavin containing monooxygenase 1 |
| GABRR2 | 1.281 | .0287 | gamma-aminobutyric acid type A receptor rho2 subunit |
| GRK5 | –1.259 | .0299 | G protein–coupled receptor kinase 5 |
| HAPLN2 | –1.387 | .0419 | hyaluronan and proteoglycan link protein 2 |
| HSD17B2 | –1.439 | .0176 | hydroxysteroid 17-beta dehydrogenase 2 |
| ITGB5 | –1.253 | .0371 | integrin subunit beta 5 |
| ITPK1 | 1.255 | .0365 | inositol-tetrakisphosphate 1-kinase |
| KDM4B | 1.2 | .03 | Lysine Demethylase 4B |
| KLK2 | 1.31 | .03 | Kallikrein Related Peptidase 2) |
| *LAMA4 | –1.715 | .0000705 | laminin subunit alpha 4 |
| LOC389895 | –1.335 | .0454 | chromosome 16 open reading frame 72-like |
| MN1 | 1.345 | .0166 | MN1 proto-oncogene, transcriptional regulator |
| MYB | 1.379 | .0102 | MYB proto-oncogene, transcription factor |
| *MYOT | 1.587 | .00042 | myotilin |
| NXNL2 | –1.348 | .03 | Nucleoredoxin-Like Protein 2 |
| PKDCC | –1.289 | .0338 | protein kinase domain containing, cytoplasmic |
| PLCE1 | –1.316 | .0145 | phospholipase C epsilon 1 |
| PLCG2 | 1.369 | .0151 | phospholipase C gamma 2 |
| PXK | –1.41 | .00239 | PX domain containing serine/threonine kinase like |
| RBM47 | 1.275 | .047 | RNA binding motif protein 47 |
| *RPS6KL1 | 1.609 | .000411 | ribosomal protein S6 kinase like 1 |
| RSPO1 | –1.447 | .0174 | R-spondin 1 |
| RUNX1 | 1.327 | .0127 | runt related transcription factor 1 |
| RXRA | 1.245 | .0295 | retinoid X receptor alpha |
| SLC7A5 | 1.37 | .03 | Solute Carrier Family 7 Member 5) |
| *SMPD3 | 1.708 | .000176 | sphingomyelin phosphodiesterase 3 |
| SPARCL1 | –1.389 | .027 | Proliferation Inducing Protein 33 |
| *THBS2 | –1.684 | .000563 | thrombospondin 2 |
| TSPAN5 | –1.33 | .0115 | tetraspanin 5 |
| USP31 | 1.29 | .038 | Ubiquitin Specific Peptidase 31 |
| WWC1 | 1.319 | .0132 | WW and C2 domain containing 1 |
*Absolute fold change >1.2, P < .05, and bound by ERα in at least 1 sample per group. **Positive fold change denotes increased expression in the Suboptimal group.