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. 2021 May 5;106(9):e3619–e3633. doi: 10.1210/clinem/dgab297

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Associations between alterations in gut microbiota, intestinal hormones, and brain activity. (A) Increased species of gut microbe in patients with obesity after VSG surgery (PreOB, n = 12; PostOB, n = 12; q < 0.05). The x-axis represents the relative abundance of each species. (B) Correlation heatmap of changes in gut microbiota with changes of BMI, TFEQ subscores, gastrointestinal hormones, and regional activity in the right putamen (n = 12 or 24). Red and blue colors represent positive and negative correlations, respectively. Symbols denote significance levels of the correlations (+q < 0.05; *q < 0.01). (C-E) Scatter plots of the relative abundance of 2 bacteria against aGLP-1 (n = 12) (C), ReHo in the right putamen (n = 24) (D), and BMI (n = 24) (E) before and after the surgery. Abbreviation: lg, log-transformed.