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. 2021 May 5;106(9):e3619–e3633. doi: 10.1210/clinem/dgab297

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Functional pathway analysis of compositional changes in gut microbiota. (A) Overall microbial functional enrichment analysis of the gut microbiota before and after surgery based on KEGG pathways (PreOB, n = 12; PostOB, n = 12). KEGG with reporter score > 1.65 or < −1.65 is shown. Blue and red colors represent after- and before-surgery enriched pathways, respectively. (B) Heatmap showing the SCFAs related GMM coverage of the species shown in Fig. 4. (C) Diagram illustrating the indicated gut-brain interaction that may mediate the surgical weight loss effects by VSG. Abbreviations: GMM, gut metabolic module; SCFAs, short-chain fatty acids.