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. 2021 May 17;106(9):e3519–e3532. doi: 10.1210/clinem/dgab320

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — A, Adjusted mean (SE) percentage change from baseline in total testosterone levels during treatment with fezolinetant vs placebo. B, Adjusted mean (SE) change from baseline in LH during treatment with fezolinetant vs placebo. C, Adjusted mean (SE) change from baseline in FSH during treatment with fezolinetant vs placebo. D, Effects of fezolinetant on LH-to-FSH ratio. All ITT population. Changes in these hormone levels were analyzed post hoc using an analysis of covariance model with treatment group as a fixed factor and baseline value as a covariate. ^aP < .05; ^bP < .01; ^cP < .001 vs placebo. Between-treatment statistical comparisons were not made on absolute LH-to-FSH ratios. Abbreviations: FSH, follicle-stimulating hormone; ITT, intent-to-treat; LH, luteinizing hormone.