Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary table of compound NEU-4854 (4aa)
| Parameters | NEU-4854 (4aa) |
|---|---|
| T. b. brucei pEC50 | 6.9 |
| MRC5 pTC50 | 4.3 |
| cLogP | 1.2 |
| PSA | 96 |
| LLE | 5.7 |
| Thermodynamic Aqueous solubility (μM) | 212 |
| MW | 312 |
| LogD7.4 | 1.9 |
| CNS MPO score | 5.0 |
| Human PPB (%) | 72 |
| HLM CLint (mL/min/mg) | 17 |
| Rat Hepatocyte CLint (mL/min/10×6) | 2.3 |
| Mouse Liver Microsome (CLint) (mL/min/g liver) | 4.1 |
| CYP3A4 Liability | No |
| Mouse plasma stability | Stable |
| Caco-2 permeability | Permeable |
