TABLE 3.
Rates of agreement between the five SARS-CoV-2 assaysa
| A/B | No. of samples with the following A/B patterna: |
Agreement (% [95% confidence interval]) |
Kappa value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| P/P | P/N | N/P | N/N | Positive, A to B | Negative, A to B | Positive, B to A | Negative, B to A | Total | ||
| Roche/Abbott | 190 | 3 | 22 | 239 | 89.6 (84.7–93.4) | 98.8 (96.4–99.7) | 98.4 (95.5–99.7) | 91.6 (87.5–94.6) | 94.5 (92.0–96.4) | 0.89 (0.85–0.93) |
| Roche/Siemens | 167 | 26 | 5 | 256 | 97.1 (93.3–99.1) | 90.8 (86.8–93.9) | 86.5 (80.9–91.0) | 98.1 (95.6–99.4) | 93.2 (91.4–95.3) | 0.86 (0.81–0.91) |
| Roche/SD Biosensor | 188 | 4 | 20 | 241 | 90.4 (85.5–94.0) | 98.4 (95.9–99.6) | 97.9 (94.8–99.4) | 92.3 (88.4–95.3) | 94.7 (92.2–96.6) | 0.89 (0.85–0.93) |
| Roche/GenScript | 148 | 45 | 3 | 258 | 98.0 (94.3–99.6) | 85.1 (80.6–89.0) | 76.7 (70.0–82.5) | 98.9 (96.7–99.8) | 89.4 (86.2–92.1) | 0.78 (0.72–0.84) |
| Abbott/Siemens | 171 | 41 | 1 | 241 | 99.4 (96.8–100.0) | 85.5 (80.8–89.4) | 80.7 (74.7–85.8) | 99.6 (97.7–100.0) | 90.7 (87.7–93.3) | 0.81 (0.76–0.87) |
| Abbott/SD Biosensor | 204 | 7 | 4 | 238 | 98.1 (95.2–99.5) | 97.1 (94.2–98.8) | 967 (93.3–98.7) | 98.3 (95.8–99.5) | 97.6 (95.7–98.8) | 0.95 (0.92–0.98) |
| Abbott/GenScript | 151 | 61 | 0 | 242 | 100.0 (97.6–100.0) | 79.9 (74.9–84.2) | 71.2 (64.6–77.2) | 100.0 (98.5–100.0) | 86.6 (83.1–89.6) | 0.73 (0.66–0.79) |
| Siemens/SD Biosensor | 170 | 1 | 38 | 244 | 81.7 (75.8–86.7) | 99.6 (97.7–100.0) | 99.4 (96.8–100.0) | 86.5 (82.0–90.3) | 91.4 (88.4–93.8) | 0.82 (0.77–0.88) |
| Siemens/GenScript | 144 | 28 | 7 | 275 | 95.4 (90.7–98.1) | 90.8 (86.9–93.8) | 83.7 (77.3–88.9) | 97.5 (95.0–99.0) | 92.3 (89.4–94.6) | 0.83 (0.78–0.89) |
| SD Biosensor/GenScript | 150 | 58 | 0 | 245 | 100.0 (97.6–100.0) | 80.9 (76.0–85.1) | 72.1 (65.5–78.1) | 100.0 (98.5–100.0) | 87.2 (83.8–90.1) | 0.74 (0.68–0.80) |
aN, negative; P, positive.