Fig. 6.

Exosome associated-tau is toxic to recipient cells. Brain sections from control and NiPSCE treated mice were immunolabeled with neuron-specific MAP2 antibodies. Hippocampal neurons ipsilateral (A) and contralateral (B) to the injection site were imaged using confocal microscopy (20X, scale bar = 10 μm). Dendritic blebbing was quantified as described in the Materials and Methods. C) Data is expressed as the mean number of blebs/length of dendrite (arbitrary units)±SEM. Data was analyzed with a 2-way ANOVA and Bonferonni post-hoc test. ***p<0.001. **p<0.01. n=17–35 dendrite per group.