Table 1.

Protein cyclin-dependent kinase inhibitors and their effect on wound healing.

CDKIs	Effects on wound healing
	reduces scarring [19]
p15
	emerges early in response to cutaneous wound in young mice [20] promotes cutaneous wound healing by inducing CYR61 [21] activate responses in normal wound healing through Keratinocyte migration and re-epithelialization [22]
p16	high expression in chronic wounds [23,24]
	delays the onset of the proliferation phase of wound healing [25] prolongs inflammation and scarring [26] delayed wound healing in aged mice [27] enhances wound healing and skin regeneration in elderly adults [27] promotes wound repair without jeopardizing tumor suppressive function [27]
p21	high expression in chronic wounds [28]
	limits cell proliferation [29]
p27	maintains cell tissue homeostasis during adulthood [29]