Table 2.

Effects of senolytic agents on senescent cells and wound healing.

Senolytic agents	Role on senescence and wound healing	References
Quercetin	Promotes senescent cell clearance in healthy tissue. Combination of quercetin and dasatinib had significant effects on health span Promotes wound healing by enhancing fibroblast proliferation and decreasing fibrosis and scarring Promotes diabetic wound healing by altering macrophage polarization Demethylates the p16ink4a gene promoter	[39,51–53]
Epigallocatechin Gallate	Decreased the level of acetylated p53 Promotes wound healing through targeting notch signaling	[54,55]
Resveratrol	Protect human lung fibroblasts from senescence caused by a high glucose environment Enhances healing by improving cell proliferation and migration	[56,57]
ABT263	Clears senescent cells induced by DNA damage in the lung Removes senescent cells induced by p53 activation in the epidermis via transgenic p14(ARF) Involvement of apoptosis-related signal pathway in the senescent cell elimination process	[58,59]
KU-60019	Promotes cutaneous wound healing in aged mice by inhibiting ATM kinase	[60]
Mmu-miR-291a-3p	Promotes excisional skin wound healing in aged mice by targeting the TGFBR2/p21 pathway	[61]