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Overexpression of Sirt1 blocks IL-1β- and TNF-α-induced neuronal apoptosis. Following transfection of neurons with pcDNA-Sirt1 expression plasmids, the cells were treated with IL-1β and TNF-α and the induction of cell apoptosis was analyzed using TUNEL staining (A and B). *P<0.05.
Abbreviation: Sirt1, Sirtuin1.
