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. Author manuscript; available in PMC: 2021 Aug 18.
Published in final edited form as: J Lung Pulm Respir Res. 2020 Nov 17;7(4):85–91.

Figure 2.

Figure 2

The MAS receptor agonist AVE-0991 restores and increases the SP-C in cultured alveolar epithelial cell (A549) monolayers under hyperoxic conditions (95% oxygen). A549 cells were cultured on 6 well plates to sub-confluence as described in Methods and were then exposed to 95% O2 in the presence or absence of MAS receptor agonist AVE0991. See Methods for details. Bars are the mean +/− S.E.M; * p<0.01 AVE Vs DMSO normoxia group, ** p<0.001 hyperoxia AVE vs normoxia DMSO group, *** p<0.01 AVE hyperoxia Vs AVE normoxia, **** p<0.001 AVE hyperoxia Vs DMSO hyperoxia using ANOVA Student-Newman-Keuls test, n=6. Western blot with control group and experimental group is shown and SP-C bands were noted at 28kDa and -actin was used for normalization.