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. 2021 May 28;49(14):e82. doi: 10.1093/nar/gkab423

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — ExM reveals colocalization between centromere-associated proteins with repetitive centromeric DNA. (A) Maximum intensity projection image of an entire expanded RPE1 cell nucleus with immunolabeled centromere associated proteins (anti-cen., red), FISH labeled alpha-satellite DNA of centromeres (α-cen., green) and Hoechst-stained nucleus (blue). (B) The distribution of anti-centromere fluorescence signal (arb. = arbitrary units) in anti-centromere, α-centromere and in randomly selected region (random) clusters within the nucleus of the cell in (A). Significance determined by a right-tailed Wilcoxon rank-sum test for anti-centromere against random, α-centromere against random, and α-centromere against anti-centromere cluster distributions. All scale bars are in pre-expansion units.