Table 3. Effect of α,β-amyrin (AMY) and fenofibrate (FEN) treatments on serum and liver parameters in mice fed on high-fat diet (HFD) or normal diet (ND) for 15 weeks.
| Parameters | ND | HFD | HFD+AMY (10 mg/kg) | HFD+AMY (20 mg/kg) | HFD+FEN (50 mg/kg) |
|---|---|---|---|---|---|
| ALT (U/L) | 46.53±0.94 | 79.12±3.75# | 51.08±1.53* | 51.87±2.65* | 52.37±2.36* |
| AST (U/L) | 48.46±2.03 | 189.50±5.99# | 77.05±4.19* | 69.30±4.66* | 65.34±4.29* |
| TG (mg/dL) | 75.75±1.52 | 93.50±7.88# | 60.00±3.53* | 69.00±5.43* | 71.17±7.70* |
| TC (mg/dL) | 95.44±3.73 | 144.3±5.44# | 125.2±10.03* | 111.5±4.27* | 93.12±4.30* |
| HDL-c (mg/dL) | 71.00±2.14 | 73.17±2.30 | 74.00±2.30 | 69.17±3.66 | 67.96±2.78 |
| VLDL-c (mg/dL) | 14.55±0.52 | 18.17±1.43# | 11.54±0.62* | 12.30±0.62* | 13.53±1.70* |
| LDL-c (mg/dL) | 25.20±4.67 | 54.32±3.33# | 43.32±2.73* | 37.84±2.42* | 28.48±5.50* |
| Liver weight (mg/g) | 42.75±1.10 | 50.72±1.40# | 36.33±1.26* | 36.99±1.45* | 41.53±1.84* |
| Liver TG (mg/g) | 1.14±0.13 | 2.34±0.06# | 0.98±0.10* | 0.53±0.05* | 0.72±0.02* |
| Liver TC (mg/g) | 0.36±0.01 | 0.56±0.03# | 0.44±0.01* | 0.45±0.01* | 0.48±0.01* |
| Hepatic glycogen (mg/g) | 29.90±2.28 | 64.29 ±11.16# | 21.31±3.82* | 21.97±1.92* | 24.06±2.14* |
Data are reported as means±SE (n=8). #P<0.05 vs ND-fed animals; *P<0.05 vs HFD-fed animals (one-way ANOVA followed by Student Newman Keul's multiple comparison post hoc test). ALT: alanine transaminase; AST: aspartate transaminase; TG: triglycerides; TC: total cholesterol; HDL-c: high-density lipoprotein cholesterol; VLDL: very-low-density lipoprotein; LDL-c: low-density lipoprotein cholesterol.