TABLE 1.
Sensitivity and specificity data of the six ELISAs included in the studya
| Assay | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|
| Mikrogen IgA | 31.6% (21.0–44.5%) | 94.0% (83.8–97.9%) |
| Mikrogen IgG | 79.0% (66.7–87.5%) | 94.0% (83.8–97.9%) |
| Euroimmun IgA | 91.2% (81.1–96.2%) | 86.0% (73.8–93.1%) |
| Euroimmun IgG | 91.2% (81.1–96.2%) | 96.0% (86.5–98.9%) |
| Serion IgA | 82.5% (70.6–90.2%) | 100.0% (92.9–100.0%) |
| Serion IgG | 98.3% (90.7–99.7%) | 100.0% (92.9–100.0%) |
a
Sensitivity data were collected on 57 samples positive in the neutralization assay. Specificity data were collected on 50 negative sera. Confidence intervals were calculated using the Wilson score method without continuity correction (25) using a confidence interval calculator sheet (26). Mikrogen, Mikrogen recomWell SARS-CoV-2 IgA/IgG (Mikrogen, Neuried, Germany); Euroimmun, Euroimmun SARS-COV-2 IgA/IgG (Euroimmun, Lübeck, Germany); Serion, Serion ELISA agile SARS-CoV-2 IgA/IgG (Institut Virion/Serion, Wuerzburg, Germany); 95% CI, 95% confidence interval.