TABLE 3.
Summary of RV94 and comparator in vitro microbiological activity against 74 Gram-positive organisms determined by broth microdilution
| Organism | Typea | No. of isolates | RV40b |
RV94 |
Telavancin |
Vancomycin |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml) | MIC:MBC | MIC (μg/ml) | MIC:MBC | MIC (μg/ml) | MIC:MBC | MIC (μg/ml) | MIC:MBC | |||
| Gram-positive aerobes | ||||||||||
| S. aureus | MSSA | 4 | 0.012 | 1 | 0.023 | 8 | 0.09 | 1 | 0.75 | 1 |
| S. aureus | MRSA | 12 | 0.008 | 1 | 0.015 | 1 | 0.06 | 1 | 0.5 | 1 |
| S. aureus | hVISA | 2 | 0.023 | 1 | 0.08 | 8 | 0.19 | 1 | 1.5 | 1 |
| S. aureus | VISA | 5 | 0.06 | 1 | 0.12 | 2 | 0.25 | 1 | 4 | 4 |
| S. aureus | VRSA | 12 | NT | NT | 4 | NT | NT | NT | >64 | NT |
| Staphylococcus epidermidis | MSSE | 1 | 0.015 | NT | 0.015 | NT | 0.12 | NT | 0.5 | NT |
| S. epidermidis | MRSE | 2 | 0.008 | 1 | 0.03 | 1 | 0.12 | 1 | 1 | 1 |
| Staphylococcus lugdunensis | 1 | 0.004 | NT | 0.015 | NT | 0.06 | NT | 0.25 | NT | |
| Staphylococcus haemolyticus | 1 | 0.015 | NT | 0.06 | NT | 0.06 | NT | 1 | NT | |
| Staphylococcus hominis | 1 | 0.015 | NT | 0.03 | NT | 0.06 | NT | 0.5 | NT | |
| Enterococcus faecalis | VSE | 2 | 0.023 | >8 | 0.03 | >8 | 0.19 | >8 | 1.5 | >8 |
| E. faecalis | VanA VRE | 1 | 0.5 | 8 | 0.03 | >8 | 1 | 8 | 128 | NT |
| Enterococcus faecium | VSE | 1 | 0.004 | NT | 0.015 | NT | 0.06 | NT | 0.5 | NT |
| E. faecium | VanA VRE | 1 | 1 | >4 | 2 | >8 | 2 | >4 | 128 | NT |
| E. faecium | VanB VRE | 1 | 0.008 | >8 | 0.03 | >8 | 0.06 | >8 | 64 | >2 |
| Streptococcus pneumoniae | PISP | 2 | 0.004 | 1 | 0.006 | 4 | 0.02 | 1 | 0.6 | 8 |
| S. pneumoniae | PRSP | 1 | ≤0.008 | NT | 0.008 | NT | 0.03 | NT | 0.25 | NT |
| Streptococcus pyogenes | 2 | 0.04 | NT | 0.012 | NT | 0.06 | NT | 0.25 | NT | |
| S. pyogenes | ermR | 1 | 0.008 | 1 | 0.008 | 1 | 0.06 | 1 | 1 | |
| Streptococcus agalactiae | 2 | 0.008 | 1 | 0.02 | 4 | 0.06 | >8 | 0.25 | 4 | |
| S. agalactiae | ermR | 1 | 0.008 | NT | 0.004 | NT | 0.06 | NT | 0.25 | NT |
| Streptococcus dysgalactiae | 3 | 0.015 | 1 | 0.008 | 4 | 0.12 | 4 | 0.25 | >8 | |
| Streptococcus anginosus | AGS | 1 | 0.015 | >8 | 0.015 | >8 | 0.06 | >8 | 0.5 | >8 |
| Streptococcus constellatus | AGS | 1 | 0.008 | NT | 0.008 | NT | 0.03 | NT | 0.25 | NT |
| Streptococcus mitis | MGS | 2 | 0.02 | 1 | 0.008 | 1 | 0.05 | 1 | 0.25 | 1 |
| Streptococcus oralis | MGS | 1 | 0.015 | NT | 0.015 | NT | 0.06 | NT | 0.5 | NT |
| Gram-positive anaerobes | ||||||||||
| Clostridioides difficile | toxAB- | 1 | 0.06 | NT | 0.015 | NT | 0.12 | NT | 0.25 | NT |
| C. difficile | ribo 027 | 1 | 0.06 | NT | 0.015 | NT | 0.12 | NT | 0.5 | NT |
| C. difficile | NAP1;ribo 027 | 1 | 0.12 | NT | 0.06 | NT | 0.12 | NT | 1 | NT |
| Clostridium. perfringens | 1 | 0.015 | NT | 0.008 | NT | 0.015 | NT | 0.25 | NT | |
| Peptostreptococcus micros | 1 | 0.06 | NT | NT | NT | 0.12 | NT | NT | NT | |
| Peptostreptococcus anaerobius | 1 | 0.008 | NT | 0.008 | NT | 0.03 | NT | 0.12 | NT | |
| Cutibacterium acnes | 2 | 0.008 | NT | 0.008 | NT | 0.02 | NT | 0.19 | NT | |
| Eggerthella lenta | 1 | NT | NT | 0.008 | NT | NT | NT | 0.5 | NT | |
MSSA, methicillin-susceptible S. aureus; MRSA, methicillin-resistant S. aureus; hVISA, heterogeneous vancomycin-intermediate S. aureus; VISA, vancomycin-intermediate S. aureus; VRSA, vancomycin-resistant S. aureus, MSSE, methicillin-susceptible S. epidermidis; MRSE, methicillin-resistant S. epidermidis; VSE, vancomycin-susceptible enterococci; VanA VRE, VanA-type vancomycin-resistant enterococci (vancomycin- and teicoplanin-resistant); VanB VRE, VanB-type vancomycin-resistant enterococci (vancomycin-resistant and teicoplanin-susceptible); PISP, penicillin-intermediate S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae; ermR, erythromycin-resistant; AGS, anginosus group streptococci; MGS, mitis group streptococci; NT, not tested.
MIC listed in the cells is the median MIC value. The MBC was measured on one organism and type except for MRSA, where the MBC represents the median of n = 5, and VISA, where it represents the median of n = 2. MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration.