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Ciprofloxacin as a trigger of SOS-induced hypermutation in E. coli E22 in vivo
| Rabbit expt | Ciprofloxacin concn (ng/ml) | Fold increase in rifampin resistance frequencya compared to E22 alone |
|---|---|---|
| 1 | 40 | 5.8 |
| 2 | 60 | 3.7 |
| 3 | 70 | 3.0 |
| 4 | 80 | 2.7 |
| 5 | 80 | 3.4 |
| 6 | 80 | 2.5 |
| Mean ± SD | 3.5 ± 1.2b | |
The rifampin concentration in the selection plates was 16 μg/ml.
Significant by a one-sided paired t test for nonparametric (skewed) data (P = 0.03).
