TABLE 3.
Probability of attainment of the target (fAUCF/MICF) × (fAUCA/MICA) = 2,709.5 across a range of amikacin and fosfomycin MICs, using 10,000 Monte Carlo simulated neonatal amikacin and fosfomycin fAUCs
| Fosfomycin MIC (mg/liter) | Probability (%) of target attainment at amikacin MIC ofa |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 mg/liter | 2 mg/liter | 4 mg/liter | 8 mg/liter | 16 mg/liter | 32 mg/liter | 64 mg/liter | 128 mg/liter | 256 mg/liter | |
| 256 | 91.33 | 51.81 | 3.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 128 | 99.42 | 91.33 | 51.81 | 3.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 64 | 99.97 | 99.42 | 91.33 | 51.81 | 3.43 | 0.00 | 0.00 | 0.00 | 0.00 |
| 32 | 100.00 | 99.97 | 99.42 | 91.33 | 51.81 | 3.43 | 0.00 | 0.00 | 0.00 |
| 16 | 100.00 | 100.00 | 99.97 | 99.42 | 91.33 | 51.81 | 3.43 | 0.00 | 0.00 |
| 8 | 100.00 | 100.00 | 100.00 | 99.97 | 99.42 | 91.33 | 51.81 | 3.43 | 0.00 |
| 4 | 100.00 | 100.00 | 100.00 | 100.00 | 99.97 | 99.42 | 91.33 | 51.81 | 3.43 |
| 2 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 99.97 | 99.42 | 91.33 | 51.81 |
| 1 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 99.97 | 99.42 | 91.33 |
a
Gray shading in the table body denotes MIC combinations with probability of target attainment of <95%.