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. 2021 Aug 14;14:1033–1043. doi: 10.2147/JAA.S316250

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© 2021 Chen et al.

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LncRNA H19 regulated Muc5ac mRNA expression via PI3K/Akt/NF-κB in 16-HBE cells. (A) After knock down of lncRNA H19 in 16-HBE cells for 24 hours, p-Akt, p-p65 and GAPDH were assayed by Western Blotting. Expressions of p-Akt and p-p65 were normalized to GAPDH. (B) Western Blotting analysis of p-Akt and p-p65 in 16-HBE cells treated with TNFα for different time. After overexpression of lncRNA H19 for 24 hours (right), 16-HBE cells was advancely treated with inhibitors of PI3K for 40 minutes and then with (D) or without (C) TNFα for 24 hours. Muc5ac was assayed by q-PCR. The study was repeated for three times. *P<0.05; **P<0.01; ***P<0.001; ns, not significant.