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Pretreatment with Tat-APPL113 influences synaptic activity-induced gene transcription. Hippocampal neurons at DIV 14‒17 (A) or hippocampal neurons (B) were untreated, treated with BMI or Tat-APPL113 (20 μM) for 1 h, or pretreated with Tat-APPL113 for 30 min followed by BMI for another 1 h. mRNA levels of CREB-related genes were measured by qRT–PCR.
