Table 1.
Demographic and Clinical Characteristics in the Responder and the Non-Responder Group
| Variables | Total Sample (N=13) | Responders(n=8) | Non-Responders (n=5) | Difference; Effect Size |
|---|---|---|---|---|
| Age | 49.5 (15.1) | 51.3 (11.5) | 46.6 (20.9) | t=0.52; d=0.30 |
| BMI | 29.0 (6.3) | 28.6 (7.0) | 29.6 (5.6) | t=−0.26; d=0.15 |
| Depression duration (weeks) | 24.0 (16–36) | 18.5 (14–31) | 26.0 (24–96) | Z=−0.74;η2=0.04 |
| Number of episodes | ||||
| Depressive | 7.6 (4.0) | 9.0 (4.3) | 5.4 (2.3) | t=−1.70; d=0.97 |
| Manic | 2.0 (2.0) | 2.5 (2.3) | 1.2 (0.8) | t=−1.18; d=0.68 |
| Hypomanic | 1.0 (0.8) | 1.3 (0.7) | 0.8 (0.8) | t=−1.04; d=0.59 |
| Mixed | 0 (0–0) | 0 (0–0) | 0 (0–0) | Z=0.07;η2<0.01 |
| Baseline results (before infusion) | ||||
| MADRS | 30.1 (9.0) | 30.1 (10.3) | 30.0 (7.7) | t=0.02; d=0.01 |
| MADRS item no. 10 | 2.0 (1–4) | 3.0 (0.5–5) | 1.0 (1–2) | Z=0.82;η2=0.05 |
| YMRS | 3.0 (1–4) | 3.5 (2–6) | 2.0 (0–3) | Z=1.33;η2=0.14 |
| BPRS | 0 (0–0) | 0 (0–1.5) | 0 (0–0) | Z=0.00;η2<0.01 |
| CADSS | 0 (0–0) | 0 (0–0) | 0 (0–0) | Z=0.63;η2=0.03 |
| Sex | ||||
| Females | 10 (76.9%) | 5 (62.5%) | 5 (100%) | Fisher=ns; φ=0.43 |
| Males | 3 (23.1%) | 3 (37.5%) | 0 (0%) | |
| Secondary | 7 (7.7%) | 5 (62.5%) | 2 (40.0%) | Fisher=1.84; V=0.38 |
| Vocational | 1 (53.8%) | 1 (12.5%) | 0 (0%) | |
| Higher | 5 (38.5%) | 2 (25.0%) | 3 (60.0%) | |
| Employment status | ||||
| Employed | 2 (15.4%) | 2 (25.0%) | 0 (0%) | Fisher=1.53; V=0.37 |
| Unemployed | 8 (61.5%) | 4 (50.0%) | 4 (80.0%) | |
| Pension | 3 (23.1%) | 2 (25.0%) | 1 (20.0%) | |
| Bipolar subtype | ||||
| I | 10 (76.9%) | 6 (75.0%) | 4 (80.0%) | Fisher=ns; φ=0.06 |
| II | 3 (23.1%) | 2 (25.0%) | 1 (20.0%) | |
| Comorbidities | ||||
| Epilepsy | 4 (30.8%) | 3 (37.5%) | 1 (20.0%) | Fisher=ns; φ=0.18 |
| Hypertension | 5 (38.5%) | 4 (50.0%) | 1 (20.0%) | Fisher=ns; φ=0.30 |
| Diabetes | 2(15.4%) | 2 (25.0%) | 0 (0%) | Fisher=ns; φ=0.34 |
| Hypercholesterolemia | 2(15.4%) | 2 (25.0%) | 0 (0%) | Fisher=ns; φ=0.34 |
| Other | 5 (38.5%) | 4 (50.0%) | 1 (20.0%) | Fisher=ns; φ=0.30 |
| Co-existing treatment | ||||
| Mood stabilizers | 10 (76.9%) | 7 (87.5%) | 3 (60.0%) | Fisher=ns; φ=0.32 |
| 2nd generation antipsychotics | 9 (69.2%) | 6 (75.0%) | 3 (60.0%) | Fisher=ns; φ=0.16 |
| Antidepressants | 9 (69.2%) | 5 (62.5%) | 4 (80.0%) | Fisher=ns; φ=−0.18 |
Notes: For the t-test, the mean and standard deviations are given; in the case of the U-test, the median and 25%-75% quartiles are given; for Fisher’s Exact Test, the number of patients and percentage are given. t – t statistics (Student’s t-test for independent samples), d – Cohen's d (effect size for t-test), Z – Z statistics (Mann–Whitney U-test for independent samples), η2 – eta-square (effect size for U-test), Fisher – Fisher’s Exact Test, ns – not significant;, φ – phi or V – Cramer’s V (effect size for contingency tables).
Abbreviations: BMI, Body Mass Index; MADRS, Montgomery–Asberg Depression Rating Scale Young; YMRS, Mania Rating Scale; CADSS, Clinician-Administered Dissociative States Scale; BPRS, Brief Psychiatric Rating Scale.